Preventive approach against drug-induced pulmonary fibrosis through the suppression of epithelial-mesenchymal transition

A number of drugs induce pulmonary injury and subsequently lead to serious lung diseases such as fibrosis the adverse drug reactions. However, an effective preventive approach against drug-induced has not been established due poor understanding common targets in a variety showing toxicity. Epithelial-mesenchymal transition (EMT), cellular phenotypic change epithelial mesenchymal state, contributes development through conversion damaged alveolar epithelium into myofibroblasts. As several with toxicity have reported EMT, EMT serves bridge between fibrosis. Accumulated evidence supports potential target Additionally, since there are mechanistic differences main pharmacological effect induced by drug, prevention based on suppression would be possible contribute continuous clinical treatment avoid EMT-mediated Furthermore, targeting seems adequate for exerting cells occurs prior pathophysiological state whole bleomycin-induced rat model. This viewpoint deals benefits perspectives approaches druginduced which rarely addressed.